U.S. Bank Center, Office building in downtown Phoenix, United States.

The U.S. Bank Center is a 407-foot (124 m) office tower at 31 floors above ground in downtown Phoenix, built in the International Style. Above the lobby sits a seven-level garage, and the tower rises another 23 floors. It is the second tallest building in Arizona.

Ground was broken in 1974 for the tower, built by M. M. Sundt Construction Company of Phoenix; it opened in 1976 as headquarters for Arizona Bancwest, parent of The Arizona Bank. The bank moved from Monroe Street and First Avenue. Del E. Webb Realty & Management was named leasing and property manager in 1975, when the building was about half complete.

The tower opened as the headquarters of Arizona Bancwest, parent of The Arizona Bank, which moved there from Monroe Street and First Avenue. Its lobby sits beneath a seven-level garage, and the 23 office floors above bring the total to 31. The bank's 1986 acquisition by Los Angeles-based Security Pacific marked the arrival of interstate banking in the state.

The tower occupies a block in downtown Phoenix, with the lobby at street level and a seven-level garage stacked directly above it. The ground-floor restaurants added in 2005 have closed, so there is no on-site dining. The building is not open to the public; the facade and its height are seen from the surrounding streets.

The building was the first high-rise in Phoenix fitted with an automatic fire sprinkler system. Above the lobby sits a seven-level garage, and the tower rises 23 more floors to 31 above ground. The U.S. Bank signs installed in February 2005 were removed after the bank left in September 2022.