Ermita de Jesús Nazareno, National monument hermitage in Popayán, Colombia

The Ermita de Jesús Nazareno is a small Catholic hermitage church standing on a slight rise in Popayán's historic centre, on calle 5. Its walls are built of rammed earth (tapial), and its facade has a curved frontispiece joining two pilasters around the door, with a espadaña bell gable above. A narrow cobbled lane, Santa Catalina, runs along its north side.

The hermitage was founded in 1617 and underwent major reconstruction work approved by the bishop in 1660. This renovation shaped the building's character and helped it survive as an important landmark through later centuries.

The temple was first dedicated to Saints Barbara and Catherine of Alexandria, saints invoked against lightning and sudden death, before being rededicated to Jesús Nazareno in 1660, a patron especially of Popayán's indigenous people. Colonial cofradías, lay brotherhoods founded to promote a devotion and hold its feast days, were based here from the hermitage's earliest years.

The hermitage stands on a small rise on Calle 5, with the narrow cobbled Calle Santa Catalina running along its north side; the street facing it, Calle de la Ermita, is the last cobbled stretch left in the city. The slope and cobbles make the approach uneven underfoot.

The burial ground lay on the adjoining land now called Loma de Cartagena, which had belonged to Lorenzo de Mendoza. Vaults and ossuaries inside the chapel were reserved for Spaniards, patrons and holders of chaplaincies. During the 1983 restoration an ossuary was found atop the side earthen walls, possibly remains from that first cemetery.