Upper Klamath National Wildlife Refuge, National wildlife refuge in Klamath County, Oregon, United States.

Upper Klamath National Wildlife Refuge is a wildlife refuge on the shores of Upper Klamath Lake in southwestern Klamath County, Oregon. Established in 1928, it holds some 14,400 acres (5,800 ha) of freshwater marshes. The refuge is part of the Klamath Basin National Wildlife Refuge Complex, administered with the other refuges from offices in Tulelake, California.

The refuge was established in 1928 as a protected area for birds and wildlife. This designation started long-term conservation efforts at the site.

Upper Klamath National Wildlife Refuge has no visitor facilities or interpretive exhibits; because it can be reached only by boat, those who come see the freshwater marshes directly, entering from Rocky Point Resort, the Rocky Point boat launch or Malone Springs. The refuge is administered with the other units of the Klamath Basin National Wildlife Refuge Complex from offices in Tulelake, California.

The refuge has no land trails; access is by boat only, from Rocky Point Resort, the Rocky Point boat launch, Malone Springs and a few neighboring ramps. Plan your outing around the water route, since the marshes are reached from Upper Klamath Lake rather than by road.

Upper Klamath National Wildlife Refuge is one of the refuges administered jointly from offices in Tulelake, California, as part of the Klamath Basin National Wildlife Refuge Complex. Its marshes lie at about 1,262 metres above sea level, and Pelican Butte rises roughly 10 km to the east.